An enterprise of the Eastern Band of the Cherokee Nation, Harrah's Cherokee Valley River Casino & Hotel is located in Murphy, North Carolina. We feature 50,000 square feet of gaming space with over 1,000 slots and 70 traditional table games, a five-outlet Food Market and a 300-room, full-service hotel.Know When to Stop Before You Start. ® Gambling Problem? Call 1-800-522-4700. Must be 21 years of age or older to gamble or enter the casino floor.